Glycan-decorated HPMA copolymers as high-affinity lectin ligands
نویسندگان
چکیده
منابع مشابه
Glycan and lectin biosensors
A short description about the importance of glycan biorecognition in physiological (blood cell type) and pathological processes (infections by human and avian influenza viruses) is provided in this review. Glycans are described as much better information storage media, compared to proteins or DNA, due to the extensive variability of glycan structures. Techniques able to detect an exact glycan s...
متن کاملDiscovering high-affinity ligands for proteins.
Drug discovery is a difficult and time-consuming process that involves the identification of potent therapeutic | TECH VI EW I agents with good bioavailability, metabolic stability, and low toxicity. An important first step in this process is the identification of molecules that bind with high affinity and selectivity to the biological target. High-affinity ligands might be discovered by screen...
متن کاملArtificial Affinity Proteins as Ligands of Immunoglobulins
A number of natural proteins are known to have affinity and specificity for immunoglobulins. Some of them are widely used as reagents for detection or capture applications, such as Protein G and Protein A. However, these natural proteins have a defined spectrum of recognition that may not fit specific needs. With the development of combinatorial protein engineering and selection techniques, it ...
متن کاملSelective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands.
The scavenger receptor C-type lectin (SRCL) is an endothelial receptor that is similar in organization to type A scavenger receptors for modified low density lipoproteins but contains a C-type carbohydrate-recognition domain (CRD). Fragments of the receptor consisting of the entire extracellular domain and the CRD have been expressed and characterized. The extracellular domain is a trimer held ...
متن کاملGlycosyldiselenides as lectin ligands detectable by NMR in biofluids.
The ability of glycosyldiselenides to act as lectin ligands and their selective detection in plasma by (77)Se NMR is reported.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polym. Chem.
سال: 2017
ISSN: 1759-9954,1759-9962
DOI: 10.1039/c7py00271h